Patients with young-onset breast cancer who carry a BRCA mutation have similar survival as non-carriers. However, BRCA mutation carriers with triple-negative breast cancer might have a survival advantage during the first few years after diagnosis compared with non-carriers. Decisions about timing of additional surgery aimed at reducing future second primary-cancer risks should take into account patient prognosis associated with the first malignancy and patient preferences.
Germline BRCA mutation and outcome in young-onset BC: a prospective cohort study
Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA Mutation Carriers
MINDACT Trial:up to 3 Positive Lymph Node Disease May Avoid Chemotherapy
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